Illustration produced for the RIKEN press release of Kato et al., Molecular Psychiatry (2018)
Kato TM, et al. (2018) Mitochondrial dysfunction causes hyperexcitability of serotonergic neurons. Molecular Psychiatry. doi: 10.1038/s41380-018-0074-9.
The illustration alludes to the duality of bipolar disorder and the interplay between serotonin and mitochondrial signaling in the brain, as proposed by the paper. The previously proposed pathways to understand the risks of bipolar disorder are intermingled via mutations in the studied gene, ANT1.